Set in 2005, Murder in the Afternoon follows friends Roman, Victor, Ethan, and Mark as they unpack their lives in a bizarrely desolate apartment complex in Eden Heights. What begins as typical roommate bickering and movie nights quickly turns into a living nightmare when they find a mysterious package containing their old home movie script alongside an ominous message. When Mark is brutally attacked in the building's forbidden basement, the remaining friends realize a real-life psycho is hunting them. Paranoia tears the group apart as they try to survive an unseen killer who considers their terror nothing more than a game.